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KMID : 0361020000430070693
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 7 p.693 ~ p.697
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Association between HLA Class Ⅱ Alleles and Response to Steroid Therapy in Sudden Sensorineural Hearing Loss
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Yeo Sang-Won
Chang Ki-Hong
Kim Tai-Gyu
Han Hoon
Choi Hee-Baeg
Suh Byung-Do
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Abstract
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Background and Objectives : This research investigated the association between HLA (human leukocyte
antigen) classⅡ alleles and the susceptibility to sudden sensorineural hearing loss, and between HLA
classⅡ alleles and the results of treatment with steroid in the Korean population.
Materials and Method : We carried out HLA-DRBI,-DQA1, -DQB1, and DPB1 genotyping in 41 patients with sudden sensorineural hearing hearing loss and in 206 healthy controls. We examined the initial hearing levels at
the onset of hearing lose and the final hearing levels after the treatment, and then evaluated for the
association with HLA class Ⅱ alleles. HLA-DRB1, DQA1, DQB1, and DPB1 genotypings were performed
by employing the sequence specific oligonucleotide probes (SSOP) method.
Results : The frequencies of HLA-DRBI, DQA1, DQB1, and DPB1 alleles were not significantly different between the patients and controls. When the association between the patients and controls. When the association between results of treatment and HLA alleles was increased, the frequencies of HLA-DRB1*14(RR=3.5, p<0.02),
-DQA1*03 and -DQA1*05 (RR=3.1, p<0.03) significantly increase, but the
frequencies of HLA-DQA1*01(RR=0.2, p<0.004) and -DQB1*06(RR=0.2, p<0.009)
significantly decreased in patients who did not respond to the steroid treatment, compared with the
controls. The frequencies of HLA-DQA1*01 (p<0.04) and -DQB1*06(p<0.02)
significantly increased while the frequency of HLA-DQA1*03(p<0.003) significantly decrease
in patients who responded well to steroid, compared with patients who did not.
Conclusion : These results suggest that the presence of HLA-DQA1*14 DQA1*03 DQA* 05might be an useful marker that implys poor prognoses whereas the presence of
HLA-DQA1*01 and DQB1*06 might be a marker implying good prognoses in
Korean patients with sudden sensorineural hearing loss.
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KEYWORD
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HLA classⅡgenes, Sudden sensorineural hearing loss
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